The AIC CARES Initiative is the continuation of the Academic Innovations Collaborative (AIC), a two-year effort by the Harvard Medical School Center for Primary Care and Harvard-affiliated teaching practices. The AIC was designed to transform primary care delivery at local clinics and community health centers. This next phase of the AIC will leverage team-based approaches to care to dramatically improve safety and reduce risk, and continue improving quality of care and patient and provider experience, in participating practices. Led by the Center for Primary Care, in partnership with Qualis Health, the CARES Initiative is supported through a partnership with CRICO/Risk Management Foundation. Seven major Harvard hospital affiliates and 20 primary care practices are engaged in this next phase of transformational work.